Details of the Target

General Information of Target

Target ID LDTP12549
Target Name Phospholipid scramblase 2 (PLSCR2)
Gene Name PLSCR2
Gene ID 57047
Synonyms
Phospholipid scramblase 2; PL scramblase 2; Ca(2+)-dependent phospholipid scramblase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGYLPPKGYAPSPPPPYPVTPGYPEPALHPGPGQAPVPAQVPAPAPGFALFPSPGPVAL
GSAAPFLPLPGVPSGLEFLVQIDQILIHQKAERVETFLGWETCNRYELRSGAGQPLGQAA
EESNCCARLCCGARRPLRVRLADPGDREVLRLLRPLHCGCSCCPCGLQEMEVQAPPGTTI
GHVLQTWHPFLPKFSIQDADRQTVLRVVGPCWTCGCGTDTNFEVKTRDESRSVGRISKQW
GGLVREALTDADDFGLQFPLDLDVRVKAVLLGATFLIDYMFFEKRGGAGPSAVTS
Target Bioclass
Transporter and channel
Family
Phospholipid scramblase family
Subcellular location
Membrane; Nucleus
Function
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.; Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.
Uniprot ID
Q9NRY7
Ensemble ID
ENST00000336685.6
HGNC ID
HGNC:16494

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.P117L .
EFO27 SNV: p.D199E .
HCC15 SNV: p.Q137K; p.E140G .
HT1376 Substitution: p.P197S .
HT3 SNV: p.P102S .
MCC13 SNV: p.E33D .
NCIH1703 SNV: p.S72F .
NCIH1793 SNV: p.G51V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C227(0.27)  LDD2207  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0628  OTUB2-COV-1 HEK-293T C227(0.27)  LDD2207  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Barttin (BSND) . Q8WZ55
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Protein FAM221B (FAM221B) FAM221 family A6H8Z2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9

References

1 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.