Details of the Target

General Information of Target

Target ID LDTP12531
Target Name CDC42 small effector protein 2 (CDC42SE2)
Gene Name CDC42SE2
Gene ID 56990
Synonyms
SPEC2; CDC42 small effector protein 2; Small effector of CDC42 protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRV
HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP
GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR
EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGTV
SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGFFLPGLFLLLVSC
VLLAKCLLHPSADGTPFPAPD
Target Bioclass
Other
Family
CDC42SE/SPEC family
Subcellular location
Cytoplasm, cytoskeleton
Function
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Uniprot ID
Q9NRR3
Ensemble ID
ENST00000360515.7
HGNC ID
HGNC:18547

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019