Details of the Target

General Information of Target

Target ID LDTP12515
Target Name Tubby-related protein 4 (TULP4)
Gene Name TULP4
Gene ID 56995
Synonyms
KIAA1397; TUBL4; TUSP; Tubby-related protein 4; Tubby superfamily protein; Tubby-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDL
AAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHET
YGHKTPY
Target Bioclass
Other
Family
TUB family
Subcellular location
Cytoplasm
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot ID
Q9NRJ4
Ensemble ID
ENST00000367094.6
HGNC ID
HGNC:15530

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E825D .
786O SNV: p.D1404Y .
AN3CA Deletion: p.R403AfsTer24 .
AU565 SNV: p.S676C .
CAL148 SNV: p.P421T .
HCT116 Deletion: p.V1022WfsTer2 .
HDMYZ SNV: p.E208K .
HS936T SNV: p.P954L .
HSC4 SNV: p.D231E .
IGROV1 SNV: p.N218K .
IPC298 SNV: p.D275E .
Ishikawa (Heraklio) 02 ER Deletion: p.V1022WfsTer2 .
JURKAT SNV: p.G147R .
KMRC1 SNV: p.T171M .
MCC26 SNV: p.E1454K .
MEWO SNV: p.P690S .
MFE296 Deletion: p.R403AfsTer24 .
MFE319 SNV: p.L982P .
MKN1 SNV: p.G1348S .
ONS76 SNV: p.Q190R .
REH Deletion: p.V1022WfsTer2 .
RKO Deletion: p.P836RfsTer30 .
SUPT1 SNV: p.R343C .
UACC62 SNV: p.P9S .
VCAP SNV: p.V301F .
WM793 SNV: p.Q1300P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C349(9.13)  LDD1706  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell-activated C349(9.13)  LDD1706  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019