Details of the Target

General Information of Target

Target ID LDTP12514
Target Name C-C motif chemokine 28 (CCL28)
Gene Name CCL28
Gene ID 56477
Synonyms
SCYA28; C-C motif chemokine 28; Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
ETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDER
QMDDLEGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGE
KCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREA
AASCMTAGVHEAQA
Target Bioclass
Cytokine and receptor
Family
Intercrine beta (chemokine CC) family
Subcellular location
Secreted
Function Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Uniprot ID
Q9NRJ3
Ensemble ID
ENST00000361115.4
HGNC ID
HGNC:17700

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NOMO1 SNV: p.A89V .
OE33 SNV: p.A27S .
ONS76 SNV: p.T120I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C99(1.99)  LDD3444  [1]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C99(3.07)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C99(4.06)  LDD2685  [1]
 LDCM0024  KB05 SNU-478 C99(1.99)  LDD3444  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein DDI1 homolog 1 (DDI1) DDI1 family Q8WTU0
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Cytokine and receptor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 10 (CXCL10) Intercrine alpha (chemokine CxC) family P02778
Platelet factor 4 (PF4) Intercrine alpha (chemokine CxC) family P02776
Stromal cell-derived factor 1 (CXCL12) Intercrine alpha (chemokine CxC) family P48061
C-C motif chemokine 17 (CCL17) Intercrine beta (chemokine CC) family Q92583
C-C motif chemokine 21 (CCL21) Intercrine beta (chemokine CC) family O00585
C-C motif chemokine 26 (CCL26) Intercrine beta (chemokine CC) family Q9Y258
C-C motif chemokine 5 (CCL5) Intercrine beta (chemokine CC) family P13501
Eotaxin (CCL11) Intercrine beta (chemokine CC) family P51671
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type 3 (DYNLT3) Dynein light chain Tctex-type family P51808

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.