Details of the Target
General Information of Target
| Target ID | LDTP12501 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dual oxidase 1 (DUOX1) | |||||
| Gene Name | DUOX1 | |||||
| Gene ID | 53905 | |||||
| Synonyms |
DUOX; LNOX1; THOX1; Dual oxidase 1; EC 1.11.1.-; EC 1.6.3.1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1 |
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| 3D Structure | ||||||
| Sequence |
MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRR
VPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVE TPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLD GSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAF GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYE WLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKG FQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLS QLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL RDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAI TIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSS PIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLF SSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVL DINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLS FREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQL AEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNI SCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQ RGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGI ILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAIL HSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLA IMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGD KLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTL TSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVS VLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEEND HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFN SLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF |
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| Target Bioclass |
Enzyme
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| Family |
Peroxidase family
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| Subcellular location |
Apical cell membrane
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| Function |
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 769P | Substitution: p.R194G | . | |||
| AU565 | SNV: p.Q451P | . | |||
| CAOV3 | Deletion: p.F1502CfsTer21 SNV: p.P1500T |
. | |||
| CHL1 | SNV: p.Y834Ter | . | |||
| EFO21 | SNV: p.L214F | . | |||
| EFO27 | SNV: p.Y1469H | . | |||
| HCC1395 | SNV: p.R43K | . | |||
| HCT15 | SNV: p.R126H | . | |||
| HELA | Substitution: p.P219S | . | |||
| HEP3B217 | SNV: p.F1501L | . | |||
| HUCCT1 | SNV: p.I1244S | . | |||
| IGR1 | SNV: p.S199Ter | . | |||
| KP4 | SNV: p.A781T; p.G784E | . | |||
| KYSE150 | SNV: p.D131H | . | |||
| LNCaP clone FGC | SNV: p.E742D | . | |||
| LS123 | SNV: p.A1017V | . | |||
| MCC13 | SNV: p.P162L | . | |||
| MDAMB436 | SNV: p.G99R | . | |||
| MELHO | SNV: p.F768S | . | |||
| MELJUSO | SNV: p.G349E | DBIA Probe Info | |||
| MEWO | SNV: p.G140R | . | |||
| NCIH1155 | SNV: p.R148K; p.A291T | . | |||
| TE1 | SNV: p.S176I | . | |||
| ZR751 | SNV: p.E271K | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C656(1.76) | LDD3375 | [1] | |
Competitor(s) Related to This Target