Details of the Target
General Information of Target
| Target ID | LDTP12500 | |||||
|---|---|---|---|---|---|---|
| Target Name | Dual oxidase 2 (DUOX2) | |||||
| Gene Name | DUOX2 | |||||
| Gene ID | 50506 | |||||
| Synonyms |
LNOX2; THOX2; Dual oxidase 2; EC 1.11.1.-; EC 1.6.3.1; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; Thyroid oxidase 2; p138 thyroid oxidase
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| 3D Structure | ||||||
| Sequence |
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAAL
DGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKK VKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYEL SQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLN KAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRC RQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPI EVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWCDS |
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| Target Bioclass |
Enzyme
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| Family |
Peroxidase family
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| Subcellular location |
Apical cell membrane
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| Function |
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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OPA-S-S-alkyne Probe Info |
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K530(6.54) | LDD3494 | [1] | |
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DBIA Probe Info |
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C804(1.84); C1520(2.17) | LDD3410 | [2] | |
Competitor(s) Related to This Target
References