Details of the Target

General Information of Target

Target ID	LDTP12464
Target Name	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (DYRK4)
Gene Name	DYRK4
Gene ID	8798
Synonyms	Dual specificity tyrosine-phosphorylation-regulated kinase 4; EC 2.7.12.1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Target Type	Literature-reported
Target Bioclass	Enzyme
Family	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
Subcellular location	Cytoplasm
Function	Possible non-essential role in spermiogenesis.
TTD ID	T20542
Uniprot ID	Q9NR20
DrugMap ID	TTCLIHJ
Ensemble ID	ENST00000010132.6
HGNC ID	HGNC:3095
ChEMBL ID	CHEMBL1075115

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 2 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
DBIA Probe Info			C504(4.08)	LDD3365	[1]
Acrolein Probe Info			N.A.	LDD0221	[2]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0107	IAA	HeLa	N.A.	LDD0221	[2]
LDCM0022	KB02	EFO-27	C504(2.72)	LDD2322	[1]
LDCM0023	KB03	EFO-27	C504(4.12)	LDD2739	[1]
LDCM0024	KB05	OVCAR-3	C504(4.08)	LDD3365	[1]
LDCM0109	NEM	HeLa	N.A.	LDD0227	[2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Heat shock protein HSP 90-alpha (HSP90AA1)	Heat shock protein 90 family	P07900
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	CMGC Ser/Thr protein kinase family	Q92630
E3 ubiquitin-protein ligase Midline-1 (MID1)	TRIM/RBCC family	O15344

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1)				Heat shock protein 90 family	P08238

The Drug(s) Related To This Target

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Leucettine L41				Small molecular drug	D04IMY

References

1	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
2	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.