Details of the Target

General Information of Target

Target ID LDTP12462
Target Name Scavenger receptor cysteine-rich type 1 protein M160 (CD163L1)
Gene Name CD163L1
Gene ID 283316
Synonyms
CD163B; M160; Scavenger receptor cysteine-rich type 1 protein M160; CD163 antigen-like 1; CD antigen CD163b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
Target Bioclass
Enzyme
Subcellular location
Secreted; Cell membrane
Uniprot ID
Q9NR16
Ensemble ID
ENST00000313599.8
HGNC ID
HGNC:30375

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E865D .
8505C SNV: p.T749A .
A172 SNV: p.G1058S .
A3KAW SNV: p.G1203D .
ABC1 SNV: p.L753V .
CAL27 Deletion: p.V707SfsTer15 .
CAL51 SNV: p.S483R .
CAL78 SNV: p.Y255H .
COLO792 SNV: p.G643E DBIA    Probe Info 
DU145 SNV: p.E1150Q .
FADU SNV: p.G611C .
HCC15 SNV: p.S1438C .
HCT116 SNV: p.P1213L .
HEC1 SNV: p.R215C .
HEC1B SNV: p.R215C .
HT115 SNV: p.N185S .
Ishikawa (Heraklio) 02 ER SNV: p.G76V; p.W283C .
JHH7 SNV: p.S201A .
JVM3 SNV: p.P988L .
MEWO SNV: p.M1411I .
MFE319 SNV: p.E490G; p.L1143F; p.A1355V .
MOLT4 SNV: p.D356Y .
NB1 SNV: p.H524Q .
NCIH1792 SNV: p.G374V .
NCIH1793 SNV: p.M1?; p.P56H .
OVK18 SNV: p.H567Y .
SKN SNV: p.G1190V .
SUPT1 SNV: p.C699G .
SW480 SNV: p.F1138L .
UACC62 SNV: p.E1146K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C524(2.28)  LDD2253  [1]
Acrolein
 Probe Info  		N.A.  LDD0226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C524(2.28)  LDD2253  [1]
 LDCM0023  KB03 A2058 C524(4.31)  LDD2670  [1]
 LDCM0024  KB05 A2058 C524(4.10)  LDD3087  [1]
 LDCM0109  NEM HeLa N.A.  LDD0226  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.