Details of the Target

General Information of Target

Target ID LDTP12452
Target Name Bridging integrator 3 (BIN3)
Gene Name BIN3
Gene ID 55909
Synonyms
Bridging integrator 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCY
LSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKI
YLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFW
ELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRIN
KRGAKNCNAIRHFENTFVVETLICGVV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function Involved in cytokinesis and septation where it has a role in the localization of F-actin.
Uniprot ID
Q9NQY0
Ensemble ID
ENST00000276416.11
HGNC ID
HGNC:1054
ChEMBL ID
CHEMBL4295959

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 Deletion: p.L41RfsTer22 .
MEWO SNV: p.P119R .
SNU308 SNV: p.L158P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K105(10.00); K157(7.86)  LDD0277  [1]
CY-1
 Probe Info  		Q37(0.00); Q42(0.00); R39(0.00); R40(0.00)  LDD0246  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA replication complex GINS protein SLD5 (GINS4) GINS4/SLD5 family Q9BRT9
Alpha-taxilin (TXLNA) Taxilin family P40222
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Dynamin-binding protein (DNMBP) . Q6XZF7
Ubiquitin-like protein 5 (UBL5) . Q9BZL1
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.