Details of the Target

General Information of Target

Target ID LDTP12447
Target Name PR domain zinc finger protein 5 (PRDM5)
Gene Name PRDM5
Gene ID 11107
Synonyms
PFM2; PR domain zinc finger protein 5; EC 2.1.1.-; PR domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGPLKGSGAAGLLSAPQPLQPPPPPPPPE
RAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFA
PLAAAAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQ
QRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEW
LRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWE
IYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTEL
LVWYNDSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLAPTTQQRSVV
FPQTPCSRNFSLLDKSGPIESGFNQINVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFK
TFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAG
ATTLNNHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily
Subcellular location
Nucleus
Function
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.
Uniprot ID
Q9NQX1
Ensemble ID
ENST00000264808.8
HGNC ID
HGNC:9349

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
L428 SNV: p.K31M .
MCC13 SNV: p.E429D .
MFE319 Deletion: p.D259MfsTer15 .
MIAPACA2 SNV: p.A213T .
OVK18 Deletion: p.D259MfsTer15
SNV: p.L380R		 .
RKO SNV: p.E603G .
TE4 Substitution: p.I369S .
U118MG SNV: p.K610E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C221(1.28)  LDD3433  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Kelly C221(1.44)  LDD2417  [1]
 LDCM0023  KB03 Kelly C221(1.50)  LDD2834  [1]
 LDCM0024  KB05 SK-N-AS C221(1.28)  LDD3433  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840