Details of the Target

General Information of Target

Target ID LDTP12445
Target Name Cyclic nucleotide-gated cation channel beta-3 (CNGB3)
Gene Name CNGB3
Gene ID 54714
Synonyms
Cyclic nucleotide-gated cation channel beta-3; Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; CNG channel beta-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
QKQGRQEALEWLIRETQPISKQH
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB3 subfamily
Subcellular location
Membrane
Function
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
TTD ID
T32227
Uniprot ID
Q9NQW8
DrugMap ID
TT0LJCG
Ensemble ID
ENST00000320005.6
HGNC ID
HGNC:2153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.L222F .
A3KAW SNV: p.N376H .
CHL1 SNV: p.P111L .
CORL88 SNV: p.L145V .
DU145 SNV: p.H768D .
FTC133 Deletion: p.N426IfsTer12
SNV: p.N426I		 .
HCT15 SNV: p.Q38H; p.A597V .
IPC298 SNV: p.V173I .
Ishikawa (Heraklio) 02 ER SNV: p.W221C .
KMS11 SNV: p.E484K .
NCIH1299 SNV: p.P59T .
NCIH2286 SNV: p.R140S .
REH SNV: p.Y200C .
SBC5 SNV: p.V580A .
TFK1 SNV: p.W221G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		K669(0.00); K674(0.00)  LDD0199  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aav-cngb3 Gene therapy D56WJV
Achm-cngb3 Gene therapy DYRC18
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-(Cis)-diltiazem Small molecular drug D00YNI

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.