Details of the Target
General Information of Target
| Target ID | LDTP12391 | |||||
|---|---|---|---|---|---|---|
| Target Name | Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) | |||||
| Gene Name | SCUBE2 | |||||
| Gene ID | 57758 | |||||
| Synonyms |
CEGP1; Signal peptide, CUB and EGF-like domain-containing protein 2; Protein CEGP1; Scube/You |
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| 3D Structure | ||||||
| Sequence |
MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE
KQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYH RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Secreted
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| Function |
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
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| TTD ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IPM Probe Info |
 |
N.A. | LDD0241 | [1] | |
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DBIA Probe Info |
 |
C177(1.82) | LDD2269 | [2] | |
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IA-alkyne Probe Info |
 |
C442(19.60) | LDD0315 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | BRX250 | C177(1.82) | LDD2269 | [2] |
| LDCM0023 | KB03 | Jurkat | C442(19.60) | LDD0315 | [3] |
| LDCM0024 | KB05 | BRX250 | C177(1.61) | LDD3103 | [2] |
| LDCM0627 | NUDT7-COV-1 | HEK-293T | C442(0.07) | LDD2206 | [4] |
| LDCM0628 | OTUB2-COV-1 | HEK-293T | C442(0.07) | LDD2207 | [4] |
References