Details of the Target

General Information of Target

Target ID LDTP12336
Target Name Calcium-binding protein 2 (CABP2)
Gene Name CABP2
Gene ID 51475
Synonyms
Calcium-binding protein 2; CaBP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function
Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina.
Uniprot ID
Q9NPB3
Ensemble ID
ENST00000294288.5
HGNC ID
HGNC:1385

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.K14E .
HT3 SNV: p.Q18H .
JURKAT SNV: p.V137M .
MCC26 SNV: p.S27F .
NCIN87 Substitution: p.G56A .
OSRC2 SNV: p.E156Ter .
RL952 Deletion: p.E147_A149del
SNV: p.N167S		 .
RPMI7951 SNV: p.V201G .
SW1271 SNV: p.P142S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C106(0.96)  LDD2107  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C106(0.96)  LDD2107  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761