Details of the Target

General Information of Target

Target ID LDTP12316
Target Name ABC-type oligopeptide transporter ABCB9 (ABCB9)
Gene Name ABCB9
Gene ID 23457
Synonyms
KIAA1520; ABC-type oligopeptide transporter ABCB9; EC 7.4.2.6; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTT
YDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVV
EDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFE
EKSGRTFLHTVCFY
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
Subcellular location
Lysosome membrane
Function
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Uniprot ID
Q9NP78
Ensemble ID
ENST00000280560.13
HGNC ID
HGNC:50
ChEMBL ID
CHEMBL1293189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S671R .
AN3CA SNV: p.A593T .
COLO792 SNV: p.V479A .
FTC133 SNV: p.G539W .
JURKAT SNV: p.T274A .
MOLT4 Deletion: p.V296SfsTer45 .
NUGC3 SNV: p.A212V .
RVH421 SNV: p.S461F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		N.A.  LDD0199  [1]

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.