Details of the Target

General Information of Target

Target ID LDTP12299
Target Name SH2 domain-containing protein 2A (SH2D2A)
Gene Name SH2D2A
Gene ID 9047
Synonyms
SCAP; TSAD; VRAP; SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQV
SKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKL
QEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAV
GELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQ
ELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQ
NFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFS
GNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Uniprot ID
Q9NP31
Ensemble ID
ENST00000368198.7
HGNC ID
HGNC:10821
ChEMBL ID
CHEMBL3217401

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.S43F .
EOL1 SNV: p.L37M .
GB1 SNV: p.G90R .
HCT15 SNV: p.G337C .
Ishikawa (Heraklio) 02 ER SNV: p.R107S .
KYSE150 SNV: p.R294W .
LOXIMVI SNV: p.D28N .
MFE319 SNV: p.P191H .
NCIH1155 SNV: p.G115V .
SNU1 SNV: p.W382C .
TE4 SNV: p.P353H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C6(1.36)  LDD3397  [1]
IA-alkyne
 Probe Info  		C34(5.99)  LDD1708  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C34(5.99)  LDD1708  [2]
 LDCM0023  KB03 DEL C6(2.48)  LDD2732  [1]
 LDCM0024  KB05 PF-382 C6(1.36)  LDD3397  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Tyrosine-protein kinase Lck (LCK) Tyr protein kinase family P06239
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Terminal nucleotidyltransferase 5A (TENT5A) TENT family Q96IP4
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 3 (ASB3) Ankyrin SOCS box (ASB) family Q9Y575
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1) WD repeat DCAF12 family Q5VU92
LIM and SH3 domain protein 1 (LASP1) . Q14847

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.