Details of the Target

General Information of Target

Target ID LDTP12291
Target Name Neurexin-3-beta (NRXN3)
Gene Name NRXN3
Gene ID 9369
Synonyms
KIAA0743; Neurexin-3-beta; Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment; NRXN3-CTF)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEE
EEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKT
QKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQS
VLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSH
LPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQA
GTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE
Target Bioclass
Other
Family
Neurexin family
Subcellular location
Presynaptic cell membrane
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Uniprot ID
Q9HDB5
Ensemble ID
ENST00000281127.11
HGNC ID
HGNC:8010

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K172(3.02)  LDD3494  [1]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888