Details of the Target
General Information of Target
| Target ID | LDTP12268 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transcription factor 7-like 1 (TCF7L1) | |||||
| Gene Name | TCF7L1 | |||||
| Gene ID | 83439 | |||||
| Synonyms |
TCF3; Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3 |
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| 3D Structure | ||||||
| Sequence |
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF
WGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ |
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| Target Bioclass |
Transcription factor
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| Family |
TCF/LEF family
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| Subcellular location |
Nucleus
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| Function |
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
 |
N.A. | LDD0241 | [1] | |
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DBIA Probe Info |
 |
C88(3.26) | LDD3376 | [2] | |
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TFBX Probe Info |
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N.A. | LDD0148 | [3] | |
Competitor(s) Related to This Target
References