Details of the Target

General Information of Target

Target ID LDTP12266
Target Name Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)
Gene Name PDE11A
Gene ID 50940
Synonyms
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; EC 3.1.4.35; EC 3.1.4.53; cAMP and cGMP phosphodiesterase 11A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFE
ELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSL
VRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSR
RLLFKKIDDAELKQEK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Cyclic nucleotide phosphodiesterase family
Subcellular location
Cytoplasm, cytosol
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
TTD ID
T99802
Uniprot ID
Q9HCR9
DrugMap ID
TTTWC79
Ensemble ID
ENST00000286063.11
HGNC ID
HGNC:8773
ChEMBL ID
CHEMBL2717

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.Y796Ter .
HCC1806 SNV: p.N372D .
HEC1 SNV: p.V141A .
NCIH1703 SNV: p.M445I .
NCIH2286 SNV: p.G348V .
RD SNV: p.D234H .
SAOS2 SNV: p.K37M .
SNU1196 SNV: p.A2T .
SW1573 SNV: p.V297I .
ZR751 SNV: p.F257L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K119(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C91(2.70)  LDD2348  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HD-MY-Z C91(2.70)  LDD2348  [2]
 LDCM0023  KB03 HD-MY-Z C91(3.31)  LDD2765  [2]
 LDCM0024  KB05 HD-MY-Z C91(3.59)  LDD3182  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840