Details of the Target

General Information of Target

Target ID LDTP12263
Target Name Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL)
Gene Name HHATL
Gene ID 57467
Synonyms
C3orf3; GUP1; KIAA1173; Protein-cysteine N-palmitoyltransferase HHAT-like protein; Glycerol uptake/transporter homolog; Hedgehog acyltransferase-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL
GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL
LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE
HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE
KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP
SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR
HK
Target Bioclass
Enzyme
Family
Membrane-bound acyltransferase family, HHAT subfamily
Subcellular location
Endoplasmic reticulum membrane
Function Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
Uniprot ID
Q9HCP6
Ensemble ID
ENST00000310417.9
HGNC ID
HGNC:13242

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C90(0.72)  LDD1702  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C90(0.72)  LDD1702  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761