Details of the Target
General Information of Target
| Target ID | LDTP12261 | |||||
|---|---|---|---|---|---|---|
| Target Name | Platelet glycoprotein VI (GP6) | |||||
| Gene Name | GP6 | |||||
| Gene ID | 51206 | |||||
| Synonyms |
Platelet glycoprotein VI; GPVI; Glycoprotein 6 |
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| 3D Structure | ||||||
| Sequence |
MAASAAAAELQASGGPRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVH
EVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNMSKYVL IDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKT KLPFIVVMNKTDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRV VGVSAVLGTGLDELFVQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDMG SVALDAGTAKDSLSPVLHPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESHEEPAFQNF MQESMAQYWKRNNK |
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| Target Type |
Clinical trial
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| Target Bioclass |
Immunoglobulin
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| Subcellular location |
Single-pass membrane protein; Cell membrane
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| Function |
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
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| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C14(6.44) | LDD2229 | [1] | |