Details of the Target

General Information of Target

Target ID LDTP12255
Target Name Plexin-A4 (PLXNA4)
Gene Name PLXNA4
Gene ID 91584
Synonyms
KIAA1550; PLXNA4A; PLXNA4B; Plexin-A4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNWNEKPKSATLPPLYPKSQPPFLHQSLINQITTTSQSSFSYPGSNQEACMYPGNSNPIS
QPLLNIQNYPQQISVSDMHNGTVVASHTSVERITYANVNGPKQLTHNLQMSSGVTQNVWL
NSPMRNPVHSHIGATVSHQTDFGANVPNMPALQSQLITSDTYSMQMQMIPSNSTRLPVAY
QGNQGLNQSFSEQQVDWTQQCISKGLTYPDYRPPPKLYRYSPQSFLPDSTIQKQNFIPHT
SLQVKNSQLLNSVLTLPSRQTSAVPSQQYATQTDKRPPPPPYNCRYGSQPLQSTQHITKH
LSMEVPQSREMLSSEIRTSFQQQWQNPNENVSTIGNFTNLKVNTNSKQPFNSPIRSSVDG
VQTLAQTNEEKIMDSCNPTSNQVLDTSVAKEKLVRDIKTLVEIKQKFSELARKIKINKDL
LMAAGCIKMTNTSYSEPAQNSKLSLKQTAKIQSGPQITPVMPENAERQTPTVVESAETNK
TQCMLNSDIQEVNCRRFNQVDSVLPNPVYSEKRPMPDSSHDVKVLTSKTSAVEMTQAVLN
TQLSSENVTKVEQNSPAVCETISVPKSMSTEEYKSKIQNENMLLLALLSQARKTQKTVLK
DANQTIQDSKPDSCEMNPNTQMTGNQLNLKNMETPSTSNVSGRVLDNSFCSGQESSTKGM
PAKSDSSCSMEVLATCLSLWKKQPSDTAKEKECDKLRTNTTAVGISKPANIHVKSPCSVV
GNSNSQNKISNPSQQTALSMVMHNYESSGINITKGTELQIAVVSPLVLSEVKTLSVKGIT
PAVLPETVYPVIKEGSVCSLQNQLAENAKATAALKVDVSGPVASTATSTKIFPLTQKEKQ
NESTNGNSEVTPNVNQGKHNKLESAIHSPMNDQQISQESRNSTVVSSDTLQIDNICSLVE
GDTSYNSQIAKIFSSLPLKMVEPQKPSLPNQQGIGSREPEKQLDNTTENKDFGFQKDKPV
QCTDVSHKICDQSKSEPPLESSFNNLETNRVILEKSSLEHATEKSTANDTCSSAAIQEDI
YPQEIDASSNYTPQDPARNEIHSDKAPVLYLHDQLSELLKEFPYGIEAVNTREGSVGQQT
TYQTSEDQTADKTSSDSKDPADQIQITILSSEQMKEIFPEQDDQPYVVDKLAEPQKEEPI
TEVVSQCDLQAPAAGQSRDSVILDSEKDDIHCCALGWLSMVYEGVPQCQCNSIKNSSSEE
EKQKEQCSPLDTNSCKQGERTSDRDVTVVQFKSLVNNPKTPPDGKSHFPELQDDSRKDTP
KTKHKSLPRTEQELVAGQFSSKCDKLNPLQNHKRKKLRFHEVTFHSSNKMTASYEQASQE
TRQKKHVTQNSRPLKTKTAFLPNKDVYKKHSSLGQSLSPEKIKLKLKSVSFKQKRKLDQG
NVLDMEVKKKKHDKQEQKGSVGATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSKF
SRILTPKEYLQRQKHKEALSNKASKKICVKNVPCDSEHMRPSKLAVQVESCGKSNEKHSS
GVQTSKESLNGLTSHGKNLKIHHSQESKTYNILRNVKEKVGGKQPDKIWIDKTKLDKLTN
ISNEAQFSQMPPQVKDQKKLYLNRVGFKCTERESISLTKLESSPRKLHKDKRQENKHKTF
LPVKGNTEKSNMLEFKLCPDILLKNTNSVEERKDVKPHPRKEQAPLQVSGIKSTKEDWLK
FVATKKRTQKDSQERDNVNSRLSKRSFSADGFEMLQNPVKDSKEMFQTYKQMYLEKRSRS
LGSSPVK
Target Bioclass
Other
Family
Plexin family
Subcellular location
Cell membrane
Function
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Uniprot ID
Q9HCM2
Ensemble ID
ENST00000321063.9
HGNC ID
HGNC:9102

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.G745S .
A2780 SNV: p.R888C .
A673 SNV: p.S1630I .
CCK81 SNV: p.R1376H .
COLO679 SNV: p.D484N .
COLO792 SNV: p.E1266K
Substitution: p.G1819E		 .
DU145 SNV: p.R38P .
HCC1395 SNV: p.S166I .
HCC15 SNV: p.P1149H .
HCT116 SNV: p.V254A .
HCT15 SNV: p.D461N; p.P1513S .
HEC1B SNV: p.C516Y; p.R938Q .
HT115 SNV: p.S571Y .
HUH28 SNV: p.E1117Ter .
IGROV1 SNV: p.E1452A .
K562 SNV: p.M1017I .
KMCH1 SNV: p.G304A .
KPL1 SNV: p.W8C .
KYSE410 SNV: p.S639Ter .
L428 SNV: p.M601I .
LN18 SNV: p.E1113Q .
MCF7 SNV: p.W8C .
MDAMB231 SNV: p.R420S .
MELJUSO SNV: p.N790S .
MEWO SNV: p.H53Y;p.A1059V;p.P1473L;p.D1569N
Substitution: p.G342S		 .
NALM6 SNV: p.A215V .
NCIH1048 SNV: p.C1190Y .
NCIH1793 Deletion: p.C672AfsTer24 .
NCIH2172 SNV: p.G1592V .
NCIH2286 SNV: p.P1204H
Substitution: p.E747L		 .
NCIH23 SNV: p.A437S; p.E1456Q .
NCIH3122 SNV: p.E773Q; p.D1012V .
PC9 SNV: p.L883P .
REC1 SNV: p.M1017I .
REH SNV: p.Y1260C .
SKNSH SNV: p.R706L .
SUIT2 SNV: p.K346I .
SUPT1 SNV: p.N113S .
YSCCC SNV: p.E378K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1542(2.08)  LDD3340  [1]
IPM
 Probe Info  		C1742(5.29)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1742(5.29)  LDD1702  [2]
 LDCM0022  KB02 Kelly C1542(2.03)  LDD2417  [1]
 LDCM0023  KB03 Kelly C1542(2.33)  LDD2834  [1]
 LDCM0024  KB05 NB1 C1542(2.08)  LDD3340  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761