Details of the Target
General Information of Target
| Target ID | LDTP12250 | |||||
|---|---|---|---|---|---|---|
| Target Name | Roundabout homolog 2 (ROBO2) | |||||
| Gene Name | ROBO2 | |||||
| Gene ID | 6092 | |||||
| Synonyms |
KIAA1568; Roundabout homolog 2 |
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| 3D Structure | ||||||
| Sequence |
MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRD
QFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCT QALWKFIKPKQPMDSKEGCEPQSASPQSKEQQGDARGSPKQDSPCIHPSEDSMDMEDSDI QIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNY ALSYTGSDNIIMASKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMC LLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCD MVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQV LDAGKLAQAVLNLRNDSTCVN |
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| Target Bioclass |
Immunoglobulin
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| Family |
Immunoglobulin superfamily, ROBO family
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| Subcellular location |
Membrane
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| Function |
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
OPA-S-S-alkyne Probe Info |
 |
K75(6.49) | LDD3494 | [1] | |
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DBIA Probe Info |
 |
C262(1.85); C384(1.44) | LDD2469 | [2] | |
Competitor(s) Related to This Target
References