Details of the Target

General Information of Target

Target ID LDTP12246
Target Name Trinucleotide repeat-containing gene 6C protein (TNRC6C)
Gene Name TNRC6C
Gene ID 57690
Synonyms
KIAA1582; Trinucleotide repeat-containing gene 6C protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNS
TCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYITQTTLARDII
EAVDCSSDILALLNDGSLFCEETEKPSDSSFTLCLTHSPLPSTSEPTTDPQASLSPMSES
TLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHSNTIDVCNTVDIKTEDLSDSLPPVCD
TVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSN
GPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSEKVQPLPISTI
IRGPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSH
SKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQR
CPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRLTLGINVTSIAVRNAS
TSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC
Target Bioclass
Other
Family
GW182 family
Function
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Uniprot ID
Q9HCJ0
Ensemble ID
ENST00000696270.1
HGNC ID
HGNC:29318

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K984(0.97)  LDD0277  [1]
IA-alkyne
 Probe Info  		C481(6.51)  LDD2157  [2]
IPM
 Probe Info  		C868(0.94)  LDD1701  [3]
DBIA
 Probe Info  		C868(1.02)  LDD1492  [4]
CY-1
 Probe Info  		Q1201(0.00); Q1203(0.00)  LDD0246  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
Compound 10
 Probe Info  		C1637(0.00); C481(0.00); C868(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		C481(0.00); C868(0.00)  LDD2213  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C868(0.34)  LDD2227  [6]
 LDCM0022  KB02 HEK-293T C868(1.02)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C868(0.99)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C868(1.01)  LDD1502  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
CCR4-NOT transcription complex subunit 7 (CNOT7) CAF1 family Q9UIV1
CCR4-NOT transcription complex subunit 6 (CNOT6) CCR4/nocturin family Q9ULM6
CCR4-NOT transcription complex subunit 6-like (CNOT6L) CCR4/nocturin family Q96LI5
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (PAN2) Peptidase C19 family Q504Q3
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) PAN3 family Q58A45
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
CCR4-NOT transcription complex subunit 10 (CNOT10) CNOT10 family Q9H9A5
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
CCR4-NOT transcription complex subunit 3 (CNOT3) CNOT2/3/5 family O75175
Polyadenylate-binding protein 1 (PABPC1) Polyadenylate-binding protein type-1 family P11940

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279