Details of the Target

General Information of Target

Target ID LDTP12206
Target Name Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)
Gene Name ARNT2
Gene ID 9915
Synonyms
BHLHE1; KIAA0307; Aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; Class E basic helix-loop-helix protein 1; bHLHe1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
DDDILDC
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).
Uniprot ID
Q9HBZ2
Ensemble ID
ENST00000303329.9
HGNC ID
HGNC:16876

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.G455V .
AGS SNV: p.Q463Ter DBIA    Probe Info 
COLO792 SNV: p.P465L DBIA    Probe Info 
DU145 SNV: p.D484H .
EFO27 SNV: p.G531R .
HCT15 SNV: p.R240K DBIA    Probe Info 
HSC3 SNV: p.R234W .
HT115 SNV: p.R159Ter .
LNCaP clone FGC SNV: p.S205L .
MEWO Substitution: p.P376F .
NCIH2286 SNV: p.V192L .
P31FUJ SNV: p.L211F .
SUPT1 SNV: p.T335I .
TOV21G SNV: p.P9T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C310(2.20)  LDD3332  [1]
IPM
 Probe Info  		C230(3.92)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C230(3.92)  LDD1702  [2]
 LDCM0022  KB02 A101D C256(3.20); C310(1.72)  LDD2250  [1]
 LDCM0023  KB03 A101D C256(3.26); C310(2.39)  LDD2667  [1]
 LDCM0024  KB05 MKN45 C310(2.20)  LDD3332  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761