Details of the Target
General Information of Target
| Target ID | LDTP12199 | |||||
|---|---|---|---|---|---|---|
| Target Name | Lysophosphatidic acid receptor 2 (LPAR2) | |||||
| Gene Name | LPAR2 | |||||
| Synonyms |
EDG4; LPA2; Lysophosphatidic acid receptor 2; LPA receptor 2; LPA-2; Lysophosphatidic acid receptor Edg-4 |
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| 3D Structure | ||||||
| Sequence |
MSPRGTGCSAGLLMTVGWLLLAGLQSARGTNVTAAVQDAGLAHEGEGEEETENNDSETAE
NYAPPETEDVSNRNVVKEVEFGMCTVTCGIGVREVILTNGCPGGESKCVVRVEECRGPTD CGWGKPISESLESVRLACIHTSPLNRFKYMWKLLRQDQQSIILVNDSAILEVRKESHPLA FECDTLDNNEIVATIKFTVYTSSELQMRRSSLPATDAALIFVLTIGVIICVFIIFLLIFI IINWAAVKAFWGAKASTPEVQSEQSSVRYKDSTSLDQLPTEMPGEDDALSEWNE |
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| Target Type |
Literature-reported
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| Target Bioclass |
GPCR
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| Family |
G-protein coupled receptor 1 family
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| Subcellular location |
Cell surface
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| Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C228(2.35) | LDD3383 | [1] | |
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NAIA_5 Probe Info |
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C225(20.00) | LDD2227 | [2] | |
Competitor(s) Related to This Target
References