Details of the Target
General Information of Target
| Target ID | LDTP12161 | |||||
|---|---|---|---|---|---|---|
| Target Name | Netrin-4 (NTN4) | |||||
| Gene Name | NTN4 | |||||
| Gene ID | 59277 | |||||
| Synonyms |
Netrin-4; Beta-netrin; Hepar-derived netrin-like protein |
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| 3D Structure | ||||||
| Sequence |
MFTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIITKRMYMESLEACRNLIP
VSRVVHNILTQLERTFNLSLLVTLFSQINLREYPNLVTIYRSFKRVGASYEWQSRDTPIL LEAPTGLAEGSSLHTPLALPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPV LPLPALIQEGRSTSVTNDKLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQE MPHSPLGSMPEIRDNSPEPNDPEEPQEVSSTPSDKKGKKRKRCIWSTPKRRHKKKSLPGG TASSRHGIQKKLKRVDQVPQKKDDSTCNSTVETRAQKARTECARKSRSEEIIDGTSEMNE GKRSQKTPSTPRRVTQGAASPGHGIQEKLQVVDKVTQRKDDSTWNSEVMMRVQKARTKCA RKSRLKEKKKEKDICSSSKRRFQKNIHRRGKPKSDTVDFHCSKLPVTCGEAKGILYKKKM KHGSSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVC CQGGQLLCCGTCPRVFHEDCHIPPVEAKRMLWSCTFCRMKRSSGSQQCHHVSKTLERQMQ PQDQLIRDYGEPFQEAMWLDLVKERLITEMYTVAWFVRDMRLMFRNHKTFYKASDFGQVG LDLEAEFEKDLKDVLGFHEANDGGFWTLP |
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| Target Bioclass |
Other
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| Subcellular location |
Secreted, extracellular space, extracellular matrix, basement membrane
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| Function | May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DU145 | SNV: p.P394L | . | |||
| IM95 | SNV: p.C508R | . | |||
| LOXIMVI | SNV: p.A388G | . | |||
| MELJUSO | SNV: p.Q148Ter | . | |||
| MEWO | SNV: p.S525L | . | |||
| MFE319 | SNV: p.W491Ter | . | |||
| MKN45 | SNV: p.M142V | . | |||
| NCIH2172 | SNV: p.G352W | . | |||
| OCUG1 | SNV: p.E59K | DBIA Probe Info | |||
| SW620 | SNV: p.P245T | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C362(1.05); C371(1.05); C329(1.00) | LDD0078 | [1] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0281 | AC21 | HEK-293T | C80(0.88) | LDD1520 | [2] |
| LDCM0289 | AC29 | HEK-293T | C80(0.68) | LDD1528 | [2] |
| LDCM0298 | AC37 | HEK-293T | C80(0.65) | LDD1537 | [2] |
| LDCM0307 | AC45 | HEK-293T | C80(1.04) | LDD1546 | [2] |
| LDCM0312 | AC5 | HEK-293T | C80(0.85) | LDD1551 | [2] |
| LDCM0316 | AC53 | HEK-293T | C80(1.14) | LDD1555 | [2] |
| LDCM0325 | AC61 | HEK-293T | C80(1.19) | LDD1564 | [2] |
| LDCM0248 | AKOS034007472 | HEK-293T | C80(0.93) | LDD1511 | [2] |
| LDCM0020 | ARS-1620 | HCC44 | C362(1.05); C371(1.05); C329(1.00) | LDD0078 | [1] |
| LDCM0409 | CL21 | HEK-293T | C80(0.99) | LDD1613 | [2] |
| LDCM0422 | CL33 | HEK-293T | C80(1.13) | LDD1626 | [2] |
| LDCM0435 | CL45 | HEK-293T | C80(1.01) | LDD1639 | [2] |
| LDCM0448 | CL57 | HEK-293T | C80(1.20) | LDD1651 | [2] |
| LDCM0461 | CL69 | HEK-293T | C80(1.29) | LDD1664 | [2] |
| LDCM0475 | CL81 | HEK-293T | C80(1.14) | LDD1678 | [2] |
| LDCM0484 | CL9 | HEK-293T | C80(0.77) | LDD1687 | [2] |
| LDCM0488 | CL93 | HEK-293T | C80(1.18) | LDD1691 | [2] |
| LDCM0022 | KB02 | 8305C | C329(1.04) | LDD2248 | [3] |
| LDCM0023 | KB03 | 8505C | C329(2.54) | LDD2666 | [3] |
| LDCM0024 | KB05 | COLO792 | C329(1.09) | LDD3310 | [3] |
References