Details of the Target
General Information of Target
| Target ID | LDTP12140 | |||||
|---|---|---|---|---|---|---|
| Target Name | Aminopeptidase RNPEPL1 (RNPEPL1) | |||||
| Gene Name | RNPEPL1 | |||||
| Gene ID | 57140 | |||||
| Synonyms |
Aminopeptidase RNPEPL1; EC 3.4.11.-; Arginyl aminopeptidase-like 1; Methionyl aminopeptidase; EC 3.4.11.18 |
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| 3D Structure | ||||||
| Sequence |
MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRL
EDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQ MKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKT ITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSL LQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRE SHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYF TSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLL DENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPA ILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEA EDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKAN RKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINI ETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPES HLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLY KDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQED VGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFG VNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLE VWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSK DSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLT DSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDV AIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWN QQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPN ADLIFKTGGRRR |
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| Target Bioclass |
Enzyme
|
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| Family |
Peptidase M1 family
|
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| Function | Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
BTD Probe Info |
 |
C66(0.92) | LDD2117 | [1] | |
|
DBIA Probe Info |
 |
C501(23.93) | LDD0209 | [2] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0222 | [3] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2225 | [4] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0176 | [5] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C66(0.92) | LDD2117 | [1] |
| LDCM0108 | Chloroacetamide | HeLa | N.A. | LDD0222 | [3] |
| LDCM0022 | KB02 | 769-P | C501(1.66) | LDD2246 | [6] |
| LDCM0023 | KB03 | Jurkat | C501(23.93) | LDD0209 | [2] |
| LDCM0024 | KB05 | NCI-H1155 | C501(1.25) | LDD3342 | [6] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C66(1.20) | LDD2123 | [1] |
| LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C66(0.58) | LDD2125 | [1] |
| LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C66(0.97) | LDD2136 | [1] |
| LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C66(0.74) | LDD2137 | [1] |
References