Details of the Target

General Information of Target

Target ID LDTP12103
Target Name Chondrolectin (CHODL)
Gene Name CHODL
Gene ID 140578
Synonyms
C21orf68; Chondrolectin; Transmembrane protein MT75
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQ
PAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSP
GSSWMKKDQPTFTLRQVGIICERLLKDYEDKIREEYEQILNTKLAEQYESFVKFTHDQIM
RRYGTRPTSYVS
Target Bioclass
Other
Subcellular location
Cytoplasm; Endoplasmic reticulum
Function May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.
Uniprot ID
Q9H9P2
Ensemble ID
ENST00000299295.7
HGNC ID
HGNC:17807

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.G113S .
GB1 SNV: p.S138F .
HT115 SNV: p.G27S .
ICC10 SNV: p.G65E .
ICC106 SNV: p.G65E .
ICC108 SNV: p.G65E .
LS513 SNV: p.S6L .
LUDLU1 SNV: p.G200V .
NCIH23 SNV: p.G212C .
NCIH3122 Deletion: .
Insertion: p.Q28FfsTer8		 .
PC9 SNV: p.T88S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C31(1.03)  LDD2263  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C31(1.03)  LDD2263  [1]
 LDCM0023  KB03 HGC-27 C31(2.77)  LDD2773  [1]
 LDCM0024  KB05 HGC-27 C31(3.43)  LDD3190  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840