Details of the Target
General Information of Target
| Target ID | LDTP12062 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein eva-1 homolog A (EVA1A) | |||||
| Gene Name | EVA1A | |||||
| Gene ID | 84141 | |||||
| Synonyms |
FAM176A; TMEM166; Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166 |
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| 3D Structure | ||||||
| Sequence |
MSELTKELMELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALEQFEGGPCAVIAPVQAF
LLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDILESACCDHSGSYCLVSWLRGKTTEETA SISGSPAESSCQVEHSSALAVEELGFERFHALIQKRSFRSLPELKDAVLDQYSMWGNKFG VLLFLYSVLLTKGIENIKNEIEDASEPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDREC SGMKLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPKFPIWIVGSETHLTVFFAKDMALVA PEAPSEQARRVFQTYDPEDNGFIPDSLLEDVMKALDLVSDPEYINLMKNKLDPEGLGIIL LGPFLQEFFPDQGSSGPESFTVYHYNGLKQSNYNEKVMYVEGTAVVMGFEDPMLQTDDTP IKRCLQTKWPYIELLWTTDRSPSLN |
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| Target Bioclass |
Transporter and channel
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| Family |
EVA1 family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function | Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
BTD Probe Info |
 |
C59(0.49) | LDD2115 | [1] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Glycophorin-A (GYPA) | Glycophorin A family | P02724 | |||
| Membrane-spanning 4-domains subfamily A member 13 (MS4A13) | MS4A family | Q5J8X5 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) | SGT family | Q96EQ0 | |||
| Tetraspanin-4 (TSPAN4) | Tetraspanin (TM4SF) family | O14817 | |||