Details of the Target

General Information of Target

Target ID LDTP12041
Target Name Transducin-like enhancer protein 6 (TLE6)
Gene Name TLE6
Gene ID 79816
Synonyms
Transducin-like enhancer protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG
AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL
DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ
DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ
PWYLRVERAITEASPAH
Target Bioclass
Other
Family
WD repeat Groucho/TLE family
Subcellular location
Cytoplasm; Nucleus
Function
Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.; [Isoform 1]: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning.
Uniprot ID
Q9H808
Ensemble ID
ENST00000246112.9
HGNC ID
HGNC:30788

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.I57V; p.R404K .
COLO792 SNV: p.E100D .
HCT15 SNV: p.G11C .
P31FUJ SNV: p.Y354H .
RL952 Insertion: p.E287GfsTer34 .
TCCSUP SNV: p.E94K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KH domain-containing protein 3 (KHDC3L) KHDC1 family Q587J8
Oocyte-expressed protein homolog (OOEP) KHDC1 family A6NGQ2
NACHT, LRR and PYD domains-containing protein 5 (NLRP5) NLRP family P59047

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255