Details of the Target

General Information of Target

Target ID LDTP12032
Target Name Pleckstrin homology domain-containing family G member 2 (PLEKHG2)
Gene Name PLEKHG2
Gene ID 64857
Synonyms
Pleckstrin homology domain-containing family G member 2; PH domain-containing family G member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRN
RAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDIK
DTLPVGFIPIQETVDTQEVAFRKKRLCIKFIPRDSTEAAICDIRIMGRTKQAPPQYTFIG
ELNSMGIWYRMGRVPRNHDSSQPTTPSQSSAASTPAPNLPRHISLTLPATFRGRNSTRTD
YEYQHSNLYAISAMDGVPFMISEKFSCVPESMQPFDLLGITIKSLAEIEKEYEYSFRTEQ
SAAARLPPSPTRCQQIPQS
Target Bioclass
Other
Function
May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). Involved in the regulation of actin polymerization.
Uniprot ID
Q9H7P9
Ensemble ID
ENST00000409797.6
HGNC ID
HGNC:29515

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.T460I .
DU145 SNV: p.P2H .
HT115 SNV: p.R463Ter; p.R818Ter .
IGROV1 SNV: p.A40D .
IM95 Deletion: p.A1300PfsTer59 .
IPC298 SNV: p.L927F .
Ishikawa (Heraklio) 02 ER SNV: p.A901V; p.K1201E .
JURKAT SNV: p.P512L .
KASUMI2 SNV: p.V425A .
KMS11 SNV: p.Y196S .
MSTO211H SNV: p.V125M .
NCIH446 SNV: p.H991R .
OE33 SNV: p.E959Ter .
ONS76 SNV: p.L1244S .
P31FUJ SNV: p.V142L .
RL952 SNV: p.Q217Ter .
SAOS2 SNV: p.G326V .
SKMEL2 SNV: p.A838T .
SKMEL28 SNV: p.E313K .
SKN SNV: p.I124T .
SNU1 Insertion: p.G976RfsTer15 .
TOV21G SNV: p.L293I; p.S815Y .
UACC257 SNV: p.L448P .
YSCCC SNV: p.S1310C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C193(1.81)  LDD3347  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H1155 C193(1.15)  LDD2508  [1]
 LDCM0023  KB03 PANC-1 C998(1.75); C433(3.99); C405(3.84)  LDD2975  [1]
 LDCM0024  KB05 NCI-H1703 C193(1.81)  LDD3347  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255