Details of the Target

General Information of Target

Target ID LDTP12029
Target Name V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Gene Name VSIR
Gene ID 64115
Synonyms
C10orf54; SISP1; VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKH
DEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLE
TEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPI
MTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEH
LPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVR
KTSDSTKMRIYLGQLQRGLFVIRRRSAA
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
TTD ID
T99704
Uniprot ID
Q9H7M9
DrugMap ID
TT51SK8
Ensemble ID
ENST00000394957.8
HGNC ID
HGNC:30085
ChEMBL ID
CHEMBL4523457

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(1.16)  LDD3334  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C83(2.27)  LDD2324  [1]
 LDCM0023  KB03 CMK C83(2.50)  LDD2719  [1]
 LDCM0024  KB05 MOLM-16 C83(1.16)  LDD3334  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Dolichol kinase (DOLK) Polyprenol kinase family Q9UPQ8
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clarin-2 (CLRN2) Clarin family A0PK11
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Solute carrier family 35 member B1 (SLC35B1) Nucleotide-sugar transporter family P78383
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Transmembrane protein 100 (TMEM100) . Q9NV29
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) . Q9H7M9
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein D (APOD) Lipocalin family P05090
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Asialoglycoprotein receptor 1 (ASGR1) . P07306
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ci-8993 Antibody DXF93J
Ca-170 Small molecular drug D09PPU
Jnj-61610588 . D0PE3Z

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853