Details of the Target
General Information of Target
| Target ID | LDTP11999 | |||||
|---|---|---|---|---|---|---|
| Target Name | Epithelial splicing regulatory protein 2 (ESRP2) | |||||
| Gene Name | ESRP2 | |||||
| Gene ID | 80004 | |||||
| Synonyms |
RBM35B; Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B |
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| 3D Structure | ||||||
| Sequence |
MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATF
IMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTV QRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKM RPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRES QEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEG VLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSG PDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFH SGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSS PHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGY VPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRK ISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFS LNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS |
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| Target Bioclass |
Other
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| Family |
ESRP family
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| Subcellular location |
Nucleus
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| Function |
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C86(2.41) | LDD3311 | [2] | |
|
IA-alkyne Probe Info |
 |
C553(0.00); C86(0.00) | LDD0162 | [3] | |
|
IPM Probe Info |
 |
C86(0.00); C577(0.00) | LDD0147 | [4] | |
|
TFBX Probe Info |
 |
C577(0.00); C86(0.00) | LDD0148 | [4] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0217 | [5] | |
|
AOyne Probe Info |
 |
13.20 | LDD0443 | [6] | |
|
NAIA_5 Probe Info |
 |
C86(0.00); C129(0.00); C173(0.00); C290(0.00) | LDD2223 | [7] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0632 | CL-Sc | Hep-G2 | C411(20.00); C173(3.84); C86(1.20) | LDD2227 | [7] |
| LDCM0634 | CY-0357 | Hep-G2 | C577(0.76); C86(0.59) | LDD2228 | [7] |
| LDCM0022 | KB02 | 22RV1 | C86(1.74); C290(1.22) | LDD2243 | [2] |
| LDCM0023 | KB03 | 22RV1 | C86(2.24); C290(1.87) | LDD2660 | [2] |
| LDCM0024 | KB05 | G361 | C86(2.41) | LDD3311 | [2] |
References