Details of the Target

General Information of Target

Target ID LDTP11985
Target Name Transmembrane protein 231 (TMEM231)
Gene Name TMEM231
Gene ID 79583
Synonyms
Transmembrane protein 231
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIG
AYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGG
DQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVE
VGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISK
NTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS
Target Bioclass
Other
Family
TMEM231 family
Subcellular location
Cell projection, cilium membrane
Function
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Uniprot ID
Q9H6L2
Ensemble ID
ENST00000258173.11
HGNC ID
HGNC:37234

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.W282C .
LS180 SNV: p.D309G .
SW756 SNV: p.R220M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C70(1.48)  LDD3334  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C70(1.51)  LDD2250  [1]
 LDCM0023  KB03 A101D C70(1.89)  LDD2667  [1]
 LDCM0024  KB05 MOLM-16 C70(1.48)  LDD3334  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840