Details of the Target

General Information of Target

Target ID LDTP11974
Target Name Protein bicaudal C homolog 1 (BICC1)
Gene Name BICC1
Gene ID 80114
Synonyms
Protein bicaudal C homolog 1; Bic-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDE
LPIAKVMKDYLKHKFDDI
Target Bioclass
Other
Family
BicC family
Subcellular location
Cytoplasm
Function Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
Uniprot ID
Q9H694
Ensemble ID
ENST00000373886.8
HGNC ID
HGNC:19351

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G863Ter .
CAMA1 SNV: p.E619K .
CCK81 SNV: p.H555R .
HT115 SNV: p.A569V; p.E687K .
KARPAS422 SNV: p.S100P; p.N260Y .
LNCaP clone FGC SNV: p.D443Y .
LS123 SNV: p.D114N .
MCC13 SNV: p.G436D .
NCIH1155 SNV: p.A263V; p.S447L .
PC9 SNV: p.D692N .
RL952 SNV: p.R200Q .
SKMEL2 SNV: p.G563C .
SNU1079 SNV: p.S799Ter .
SW1783 SNV: p.R961H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K398(9.84)  LDD0277  [1]
DBIA
 Probe Info  		C164(1.80)  LDD3369  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C164(2.00)  LDD2247  [2]
 LDCM0023  KB03 786-O C164(2.27)  LDD2664  [2]
 LDCM0024  KB05 OAW-42 C164(1.80)  LDD3369  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.