Details of the Target

General Information of Target

Target ID LDTP11973
Target Name Ankyrin repeat and SOCS box protein 7 (ASB7)
Gene Name ASB7
Gene ID 140460
Synonyms
Ankyrin repeat and SOCS box protein 7; ASB-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVL
GTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETI
EQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDPVWNIQIARMLELPTIYRKVYDQ
PFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLAN
QPVIHSASSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDL
HRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVST
MEHYYTAF
Target Bioclass
Other
Family
Ankyrin SOCS box (ASB) family
Function
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot ID
Q9H672
Ensemble ID
ENST00000332783.12
HGNC ID
HGNC:17182

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G402 SNV: p.D316G .
HT115 SNV: p.R287Ter .
NCIH1155 SNV: p.R31Ter .
RH41 SNV: p.L146V .
SKNMC SNV: p.G214R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264