Details of the Target

General Information of Target

Target ID LDTP11954
Target Name Piezo-type mechanosensitive ion channel component 2 (PIEZO2)
Gene Name PIEZO2
Gene ID 63895
Synonyms
C18orf30; C18orf58; FAM38B; Piezo-type mechanosensitive ion channel component 2; Protein FAM38B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
Target Bioclass
Transporter and channel
Family
PIEZO (TC 1.A.75) family
Subcellular location
Membrane
Function
Pore-forming subunit of a mechanosensitive non-specific cation channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.
Uniprot ID
Q9H5I5
Ensemble ID
ENST00000302079.10
HGNC ID
HGNC:26270

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C668(1.49)  LDD3374  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C375(1.95); C668(1.24)  LDD2253  [1]
 LDCM0023  KB03 A2058 C375(4.83); C668(2.23)  LDD2670  [1]
 LDCM0024  KB05 OCUM-1 C668(1.49)  LDD3374  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255