Details of the Target

General Information of Target

Target ID LDTP11918
Target Name Nuclear RNA export factor 3 (NXF3)
Gene Name NXF3
Gene ID 56000
Synonyms
TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI
LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY
TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ
VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ
KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE
LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG
RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN
CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV
TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA
CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR
LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP
DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL
HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS
NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS
VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE
TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY
Target Bioclass
Other
Family
NXF family
Subcellular location
Nucleus
Function May function as a tissue-specific nuclear mRNA export factor.
Uniprot ID
Q9H4D5
Ensemble ID
ENST00000395065.8
HGNC ID
HGNC:8073

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.T502A .
HCC827 SNV: p.R76W .
HT115 SNV: p.S531Ter .
KYSE150 SNV: p.A372T .
MFE319 SNV: p.Q347Ter .
NCIH146 SNV: p.E93D .
OPM2 SNV: p.D310V .
SKOV3 SNV: p.R28G .
SNU1 SNV: p.R398K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C320(1.96)  LDD3334  [1]
BTD
 Probe Info  		C331(0.73)  LDD2107  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 JURL-MK1 C320(1.07)  LDD2410  [1]
 LDCM0023  KB03 K052 C320(2.32)  LDD2844  [1]
 LDCM0024  KB05 MOLM-16 C320(1.96)  LDD3334  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C331(0.73)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C331(0.55)  LDD2109  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C331(1.07)  LDD2125  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C331(0.93)  LDD2136  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C331(0.87)  LDD2146  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ski-like protein (SKIL) SKI family P12757
NTF2-related export protein 1 (NXT1) . Q9UKK6
NTF2-related export protein 2 (NXT2) . Q9NPJ8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060