Details of the Target

General Information of Target

Target ID LDTP11892
Target Name SPARC-related modular calcium-binding protein 2 (SMOC2)
Gene Name SMOC2
Gene ID 64094
Synonyms
SMAP2; SPARC-related modular calcium-binding protein 2; Secreted modular calcium-binding protein 2; SMOC-2; Smooth muscle-associated protein 2; SMAP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEEDEEARALLAGGPDEADRGAPAAPGALPALCDPSRLAHRLLVLLLMCFLGFGSYFCY
DNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIRWGTIIFSCFV
CIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSM
ARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGITCILSLICALALAYLDQRAE
RILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQ
AASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMC
LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFL
EVFFIACVSLSLLSVVLLYLVNRAQGGNLNYSARQREEIKFSHTE
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
Uniprot ID
Q9H3U7
Ensemble ID
ENST00000354536.9
HGNC ID
HGNC:20323

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P4S .
COLO792 SNV: p.P270L .
G361 SNV: p.P230R .
HCC827 SNV: p.A292P .
HCT116 SNV: p.Q229K .
MOLT4 Insertion: p.N232EfsTer8 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2224  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264