Details of the Target

General Information of Target

Target ID LDTP11889
Target Name Semaphorin-6B (SEMA6B)
Gene Name SEMA6B
Gene ID 10501
Synonyms
SEMAN; SEMAZ; Semaphorin-6B; Semaphorin-Z; Sema Z
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRAPHFMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELG
LDFQRFLTLNRTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVENCAVRGKLTDE
CYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAI
FAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFF
REVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVL
QALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPV
SEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSR
ALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCS
GKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGWH
SSRGCVDIRGSGGTDVDQAGNQESMEHGDCQDGATGSQSGPGDSAYGVRRDLPPASASRS
VPIPLLLASVAAAFALGASVSGLLVSCACRRAHRRRGKDIETPGLPRPLSLRSLARLHGG
GPEPPPPSKDGDAVQTPQLYTTFLPPPEGVPPPELACLPTPESTPELPVKHLRAAGDPWE
WNQNRNNAKEGPGRSRGGHAAGGPAPRVLVRPPPPGCPGQAVEVTTLEELLRYLHGPQPP
RKGAEPPAPLTSRALPPEPAPALLGGPSPRPHECASPLRLDVPPEGRCASAPARPALSAP
APRLGVGGGRRLPFSGHRAPPALLTRVPSGGPSRYSGGPGKHLLYLGRPEGYRGRALKRV
DVEKPQLSLKPPLVGPSSRQAVPNGGRFNF
Target Bioclass
Other
Family
Semaphorin family
Subcellular location
Cell membrane
Function
Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
Uniprot ID
Q9H3T3
Ensemble ID
ENST00000586582.6
HGNC ID
HGNC:10739

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.Q696Ter .
AN3CA SNV: p.G448C .
CCK81 SNV: p.A184V .
DAOY SNV: p.T283M .
HCT116 SNV: p.A345V; p.R625C .
HELA SNV: p.L593R
Substitution: p.R590Q		 .
HUH28 SNV: p.F244L .
ICC10 SNV: p.P662L .
IGROV1 Deletion: p.A880RfsTer92 .
IPC298 SNV: p.P662L .
J82 SNV: p.L753M .
KYSE410 SNV: p.C144Y .
LN229 SNV: p.P229T .
MFE296 Insertion: p.A880GfsTer144 .
MFE319 Insertion: p.A764RfsTer260 .
NCIH1155 SNV: p.T309M .
NCIH661 SNV: p.L191P .
OVK18 Deletion: p.A880RfsTer92 .
RKO Deletion: p.M383CfsTer22 .
SKHEP1 SNV: p.P838L .
SUPT1 SNV: p.A335T .
TOV21G SNV: p.P515H .
WM115 SNV: p.H221Q .
WM2664 Insertion: p.D549RfsTer16 .
WM793 SNV: p.P58L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C486(2.87)  LDD3345  [1]
IPM
 Probe Info  		C116(14.03); C174(0.53)  LDD1701  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C526(1.11); C532(1.11); C116(1.01)  LDD2171  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C116(5.43); C486(1.12)  LDD1702  [2]
 LDCM0022  KB02 A2058 C486(2.46)  LDD2253  [1]
 LDCM0023  KB03 MDA-MB-231 C116(14.03); C174(0.53)  LDD1701  [2]
 LDCM0024  KB05 NCI-H1650 C486(2.87)  LDD3345  [1]
 LDCM0021  THZ1 HCT 116 C526(1.11); C532(1.11); C116(1.01)  LDD2173  [4]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.