Details of the Target
General Information of Target
| Target ID | LDTP11886 | |||||
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| Target Name | Thiamin pyrophosphokinase 1 (TPK1) |
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| Gene Name | TPK1 | |||||
| Gene ID | 27010 | |||||
| Synonyms |
Thiamin pyrophosphokinase 1; hTPK1; EC 2.7.6.2; Placental protein 20; PP20; Thiamine pyrophosphokinase 1 |
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| 3D Structure | ||||||
| Sequence |
MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAG
AGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFL LEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSP RLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFR HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLV GVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL |
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| Target Bioclass |
Enzyme
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| Family |
Thiamine pyrophosphokinase family
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| Function | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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IA-alkyne Probe Info |
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N.A. | LDD0166 | [1] | |