Details of the Target

General Information of Target

Target ID LDTP11847
Target Name Chordin (CHRD)
Gene Name CHRD
Gene ID 8646
Synonyms
Chordin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDP
GPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLA
ALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVD
VNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
Target Bioclass
Other
Family
Chordin family
Subcellular location
Secreted
Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Uniprot ID
Q9H2X0
Ensemble ID
ENST00000204604.6
HGNC ID
HGNC:1949

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.E500K .
CAL27 SNV: p.A648V .
CCK81 SNV: p.Y567H .
ETK1 SNV: p.C525W .
Ishikawa (Heraklio) 02 ER Deletion: p.A856PfsTer40 .
JURKAT SNV: p.R597L .
MFE319 SNV: p.G435D .
NCIH1155 SNV: p.A812V .
OVK18 Deletion: p.Q859SfsTer37 .
REH SNV: p.A689S .
TGBC52TKB SNV: p.A529T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C121(0.90); C125(0.90); C902(0.92); C909(0.92)  LDD2171  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C121(0.90); C125(0.90); C902(0.92); C909(0.92)  LDD2171  [1]
 LDCM0021  THZ1 HCT 116 C121(0.90); C125(0.90); C902(0.92); C909(0.92)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853