Details of the Target

General Information of Target

Target ID LDTP11843
Target Name Disintegrin and metalloproteinase domain-containing protein 7 (ADAM7)
Gene Name ADAM7
Gene ID 8756
Synonyms
GP83; Disintegrin and metalloproteinase domain-containing protein 7; ADAM 7; Sperm maturation-related glycoprotein GP-83
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC
GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Target Bioclass
Enzyme
Subcellular location
Membrane
Function
Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development. Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance. Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation. This is a non catalytic metalloprotease-like protein.
Uniprot ID
Q9H2U9
Ensemble ID
ENST00000175238.10
HGNC ID
HGNC:214

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.L173P .
CCK81 Deletion: p.L594YfsTer29 .
COLO792 SNV: p.E87K .
HCT15 SNV: p.M472I .
HT SNV: p.M390T .
ICC3 SNV: p.P181L .
JURKAT SNV: p.C499W .
MDST8 SNV: p.W252Ter .
MELJUSO SNV: p.G302E; p.F593L .
MV411 SNV: p.E518D .
NALM6 SNV: p.C621Y; p.M624V .
NCIH23 SNV: p.G363R .
SKMEL28 SNV: p.M359I .
SKMEL5 SNV: p.H243Y .
SUIT2 SNV: p.G302E .
TC71 SNV: p.G26V; p.P478S .
TE10 SNV: p.Q721H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264