Details of the Target
General Information of Target
| Target ID | LDTP11832 | |||||
|---|---|---|---|---|---|---|
| Target Name | S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2) | |||||
| Gene Name | BHMT2 | |||||
| Gene ID | 23743 | |||||
| Synonyms |
S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; EC 2.1.1.10; Betaine--homocysteine S-methyltransferase 2 |
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| 3D Structure | ||||||
| Sequence |
MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIA
WGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNGNITAQGPSIQPVHKAESS TDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSINGHFYNHKTSV FTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGERTKLKDCEYPL ISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLT MKFQALRLTMLQRLEQLVEAK |
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| Target Bioclass |
Enzyme
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| Function | Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C208(0.99); C177(0.94); C192(0.94) | LDD0078 | [1] | |
Competitor(s) Related to This Target
References