Details of the Target

General Information of Target

Target ID LDTP11831
Target Name Ras association domain-containing protein 4 (RASSF4)
Gene Name RASSF4
Gene ID 83937
Synonyms
Ras association domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRMSLAQRVLLTWLFTLLFLIMLVLKLDEKAPWNWFLIFIPVWIFDTILLVLLIVKMAGR
CKSGFDPRHGSHNIKKKAWYLIAMLLKLAFCLALCAKLEQFTTMNLSYVFIPLWALLAGA
LTELGYNVFFVRD
Target Bioclass
Other
Function Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
Uniprot ID
Q9H2L5
Ensemble ID
ENST00000340258.10
HGNC ID
HGNC:20793

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.C92Y .
CAL33 SNV: p.Q107K .
HCC1395 SNV: p.E128Ter .
KP4 SNV: p.L288V .
NCIH2291 SNV: p.S168C .
TKKK SNV: p.R154S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C145(0.00); C33(0.00)  LDD0241  [1]
IA-alkyne
 Probe Info  		C249(1.14)  LDD0304  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
W1
 Probe Info  		N.A.  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0131  RA190 MM1.R C249(1.14)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase 3 (STK3) STE Ser/Thr protein kinase family Q13188
Serine/threonine-protein kinase 4 (STK4) STE Ser/Thr protein kinase family Q13043
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Melanoma-associated antigen 6 (MAGEA6) . P43360

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264