Details of the Target
General Information of Target
| Target ID | LDTP11822 | |||||
|---|---|---|---|---|---|---|
| Target Name | CXXC-type zinc finger protein 4 (CXXC4) | |||||
| Gene Name | CXXC4 | |||||
| Synonyms |
IDAX; CXXC-type zinc finger protein 4; Inhibition of the Dvl and axin complex protein |
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| 3D Structure | ||||||
| Sequence |
MTTKNLETKVTVTSSPIRGAGDGMETEEPPKSVEVTSGVQSRKHHSLQSPWKKAVPSESP
GVLQLGKMLTEKAMEVKAVRILVPKAAITHDIPNKNTKVKSLGHHKGEFLGQSEGVIEPN KELSEVKNVLEKLKNSERRLLQDKEGLSNQLRVQTEVNRELKKLLVASVGDDLQYHFERL AREKNQLILENEALGRNTAQLSEQLERMSIQCDVWRSKFLASRVMADELTNSRAALQRQN RDAHGAIQDLLSEREQFRQEMIATQKLLEELLVSLQWGREQTYSPSVQPHSTAELALTNH KLAKAVNSHLLGNVGINNQKKIPSTVEFCSTPAEKMAETVLRILDPVTCKESSPDNPFFE SSPTTLLATKKNIGRFHPYTRYENITFNCCNHCRGELIAL |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm
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| Function |
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
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| Uniprot ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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N.A. | LDD0241 | [1] | |