Details of the Target

General Information of Target

Target ID LDTP11808
Target Name Synaptotagmin-4 (SYT4)
Gene Name SYT4
Gene ID 6860
Synonyms
KIAA1342; Synaptotagmin-4; Synaptotagmin IV; SytIV
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPRQPHHDLPP
GGSQDGDLKEPTERVTRDLSSGAPRGRNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMP
AAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAVTPRH
VSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFD
RQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREAL
RTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLS
LIRAPRNLTFPRFKDRHSQEARTTARIAHQYFAQLSALQRQRTYDFYYMDYLMFNYSKPF
ADLY
Target Bioclass
Other
Family
Synaptotagmin family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
Function
Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes.
Uniprot ID
Q9H2B2
Ensemble ID
ENST00000255224.8
HGNC ID
HGNC:11512

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.T231A .
L428 SNV: p.P50S .
MEWO SNV: p.E235K .
OCILY3 SNV: p.T224S .
SKMEL5 SNV: p.D369N .
SNU869 SNV: p.R280K .
SW1271 SNV: p.P181T; p.H420Q .
SW1573 SNV: p.Y193Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C423(1.41)  LDD3344  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 22RV1 C409(1.52)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C409(2.13)  LDD2660  [1]
 LDCM0024  KB05 NCI-H146 C423(1.41)  LDD3344  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12) Complex I NDUFA12 subunit family Q9UI09
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Next to BRCA1 gene 1 protein (NBR1) . Q14596

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.