Details of the Target

General Information of Target

Target ID LDTP11805
Target Name 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)
Gene Name ALDH8A1
Gene ID 64577
Synonyms
ALDH12; 2-aminomuconic semialdehyde dehydrogenase; EC 1.2.1.32; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKAT
PPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Cytoplasm
Function Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
Uniprot ID
Q9H2A2
Ensemble ID
ENST00000265605.7
HGNC ID
HGNC:15471

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KPL1 SNV: p.P319S .
MCC26 SNV: p.P153S .
MCF7 SNV: p.P319S .
MFE319 SNV: p.P200S .
NCIH1993 SNV: p.G370C .
NUGC3 Deletion: p.M460Ter .
SNGM SNV: p.A171V .
TOV21G SNV: p.G202C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C287(2.45)  LDD1699  [1]
DBIA
 Probe Info  		C247(1.56)  LDD2252  [2]
IPM
 Probe Info  		C289(7.82); C287(7.82)  LDD1701  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C287(2.04)  LDD1702  [1]
 LDCM0022  KB02 A204 C247(1.56)  LDD2252  [2]
 LDCM0023  KB03 MDA-MB-231 C289(7.82); C287(7.82)  LDD1701  [1]
 LDCM0024  KB05 A204 C247(4.18)  LDD3086  [2]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840