Details of the Target

General Information of Target

Target ID LDTP11794
Target Name Cadherin-23 (CDH23)
Gene Name CDH23
Gene ID 64072
Synonyms
KIAA1774; KIAA1812; Cadherin-23; Otocadherin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Uniprot ID
Q9H251
Ensemble ID
ENST00000224721.12
HGNC ID
HGNC:13733

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.D127G .
A549 SNV: p.D553Y .
AN3CA SNV: p.C1882Y .
CALU6 Deletion: p.Q1336RfsTer29 .
CCK81 SNV: p.N1857D .
CHL1 SNV: p.G2854E .
COLO792 SNV: p.L2175F .
DU145 SNV: p.C1882Y; p.A2656V .
HCT116 SNV: p.Q579Ter .
HCT15 SNV: p.V1244L .
HT SNV: p.H2977R .
HT115 SNV: p.A643V .
HUH28 SNV: p.M2596L .
IGR37 SNV: p.E2135K .
IGR39 SNV: p.E2135K .
IGROV1 Deletion: p.M1828CfsTer25 .
KARPAS422 SNV: p.T149A .
KMRC1 SNV: p.D2695Y .
KURAMOCHI SNV: p.E2588Ter .
KYSE150 SNV: p.A1443T .
LN229 SNV: p.A1482V .
LOXIMVI SNV: p.G1369D; p.Y1748N .
LS180 SNV: p.G68C .
LS513 SNV: p.R2304W .
MCC13 SNV: p.E1199K .
MEWO SNV: p.Y273Ter; p.G1435R; p.G2213V; p.G2550S .
MFE319 Deletion: p.G1251AfsTer18
SNV: p.P1984L		 .
MOLT4 SNV: p.R1247H; p.R2743P; p.D2874N; p.A2944T .
NALM6 SNV: p.R116Q .
NCIH1155 SNV: p.R2743C .
NCIH1944 SNV: p.S1475F .
NCIH2172 Insertion: p.S326IfsTer2
SNV: p.Q263L		 .
NCIH2286 SNV: p.T198S; p.T2237K .
NCIH23 SNV: p.R1895L .
OCIAML2 SNV: p.D2695A .
RCC10RGB SNV: p.V66M .
RH30 SNV: p.D2464Y .
RKO SNV: p.H440R; p.G864R; p.R1826W .
RL952 SNV: p.S2014N .
SG231 SNV: p.I2118V .
SNU1 SNV: p.D2169V .
SW1271 SNV: p.T32N .
SW837 SNV: p.T2618P .
T24 SNV: p.A356P .
TE4 SNV: p.N2398Y .
TOV21G SNV: p.A2859S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K1080(0.87)  LDD0274  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270