Details of the Target

General Information of Target

Target ID LDTP11783
Target Name Epsin-3 (EPN3)
Gene Name EPN3
Gene ID 55040
Synonyms
Epsin-3; EPS-15-interacting protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKE
FLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQ
RHYDEDSAIGPRSPYGFRHGASVNYDDY
Target Bioclass
Other
Family
Epsin family
Subcellular location
Cytoplasm
Uniprot ID
Q9H201
Ensemble ID
ENST00000268933.8
HGNC ID
HGNC:18235

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A617S .
HCC1937 SNV: p.Q213L .
HCT15 SNV: p.M266I; p.P450H .
JEKO1 SNV: p.P619S .
KYSE30 Deletion: p.P600RfsTer64 .
MFE280 SNV: p.S189Y .
MOLT4 SNV: p.S296N .
P31FUJ SNV: p.P622Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y186(9.73)  LDD3495  [1]
DBIA
 Probe Info  		C96(1.95)  LDD3320  [2]
HHS-465
 Probe Info  		Y17(4.56)  LDD2237  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
HHS-475
 Probe Info  		Y17(0.59)  LDD2238  [3]
HHS-482
 Probe Info  		Y17(0.58)  LDD2239  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 BRX211 C96(1.95)  LDD2268  [2]
 LDCM0023  KB03 ABC-1 C96(2.51)  LDD2679  [2]
 LDCM0024  KB05 RVH421 C96(1.95)  LDD3320  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.